Home

enantioenriched

Enantioenriched describes a mixture of enantiomers that contains more of one enantiomer than the other. In this context, the enantiomeric excess (ee) is greater than zero but less than 100 percent. If the ee is 100 percent, the mixture is enantiopure; if the ee is 0 percent, the mixture is racemic.

Enantiomeric excess is calculated as ee = |[R] − [S]| / ([R] + [S]) × 100%, where [R] and [S]

Enantioenrichment can result from various processes, including asymmetric synthesis that biases formation toward one enantiomer, chiral

Measurement and reporting of ee typically rely on chiral separation techniques such as chiral chromatography, or

In practice, enantioenriched materials are important in chemical and pharmaceutical contexts where the activity, safety, or

are
the
amounts
of
the
two
enantiomers.
For
example,
a
mixture
containing
72%
of
one
enantiomer
and
28%
of
the
other
has
an
ee
of
44%.
A
60:40
mixture
has
an
ee
of
20%.
resolution
that
separates
enantiomers,
or
kinetic
resolution
that
converts
or
removes
one
enantiomer
faster
than
the
other.
The
term
emphasizes
the
presence
of
a
preferred
enantiomer
without
implying
complete
purity.
on
methods
like
optical
rotation
with
reference
standards.
While
optical
rotation
can
provide
a
clue,
it
does
not
unambiguously
determine
ee
without
knowledge
of
the
specific
rotation
of
the
pure
enantiomer.
regulation
of
a
product
depends
on
the
predominance
of
one
enantiomer
over
the
other.