eIF4BH

eIF4BH is a protein that plays a role in the process of translation initiation in eukaryotic cells. It is a component of the eIF4F complex, a multi-subunit assembly that is crucial for binding to the messenger RNA (mRNA) cap structure and unwinding secondary structures within the mRNA. Specifically, eIF4BH is thought to interact with eIF4B and eIF4A, other members of the eIF4F complex. This interaction is believed to enhance the helicase activity of eIF4A, which is essential for scanning the mRNA to find the start codon. The precise mechanism by which eIF4BH contributes to translation initiation is still an area of active research, but it is understood to be a regulatory factor that can influence the efficiency of protein synthesis. Dysregulation of translation initiation is implicated in various cellular processes and diseases, suggesting that eIF4BH could be a target for therapeutic intervention. Further studies are ongoing to fully elucidate its functions and interactions within the translational machinery.