eIF1X

eIF1X, also known as eukaryotic translation initiation factor 1X, is a protein involved in the process of protein synthesis in eukaryotic cells. It is a component of the eukaryotic translation initiation factor 1 (eIF1) complex, which plays a crucial role in the early stages of translation initiation.

The primary function of eIF1X is to assist in the recognition of the start codon (AUG) on messenger RNA (mRNA) by the small ribosomal subunit. During translation initiation, the small ribosomal subunit, along with eIFs, scans the mRNA molecule to locate the start codon. eIF1X, as part of the eIF1 complex, helps to stabilize the interaction between the small ribosomal subunit and the mRNA, and contributes to the accurate selection of the correct start codon, thereby ensuring the proper initiation of protein synthesis.

Mutations or dysregulation of eIF1X have been linked to certain cellular processes and disease states, although research in this area is ongoing. Its precise contributions to these conditions are still being investigated. The interaction of eIF1X with other translation initiation factors and ribosomal components is essential for the overall efficiency and fidelity of protein synthesis. Understanding the role of eIF1X provides insight into the complex machinery that governs gene expression in eukaryotes.