dózistolást

Dózistolást, a term originating from Hungarian, translates to "dose escalation" or "dose increase" in English. It refers to the process of gradually increasing the amount of a substance or treatment administered to a patient or experimental subject. This is a common practice in various fields, most notably in pharmacology and clinical trials.

In drug development, dose escalation is a critical phase in determining the safety and efficacy of a new medication. Researchers start with a very low dose and systematically increase it in subsequent participants or groups. The goal is to find the maximum tolerated dose (MTD), which is the highest dose that can be given without causing unacceptable side effects. This process helps establish a safe dosage range for further studies.

Beyond clinical trials, dose escalation can be employed in therapeutic settings. For instance, when treating chronic conditions, physicians may gradually increase a patient's medication dose to achieve the desired therapeutic effect while minimizing initial adverse reactions. Conversely, the term can also describe a situation where a dose is unintentionally increased beyond the prescribed or safe level, which can be a sign of an error in administration or a misunderstanding of the dosage instructions. The context in which "dózistolást" is used is crucial for understanding its specific meaning.