disulfidiexchange
Disulfide exchange is a chemical reaction that involves the breaking and forming of disulfide bonds (S-S) between two thiol groups (-SH) of different molecules. This process is crucial in various biological and chemical contexts, including protein folding, protein-protein interactions, and the function of enzymes. Disulfide exchange reactions are typically facilitated by enzymes known as disulfide isomerases, which catalyze the rearrangement of disulfide bonds to ensure the correct folding and stability of proteins.
The mechanism of disulfide exchange involves the nucleophilic attack of a thiolate ion (R-S-) on a disulfide
Disulfide exchange reactions are not limited to biological systems. They also occur in synthetic chemistry, where
The study of disulfide exchange has significant implications for understanding protein structure, function, and misfolding, as