dihydrotestosteronereceptor

The dihydrotestosterone receptor, often abbreviated as DHTR or ARv7 when referring to a specific splice variant, is a protein that acts as a receptor for androgens, primarily dihydrotestosterone (DHT). It belongs to the nuclear receptor superfamily. DHT is a potent androgen derived from testosterone and plays a crucial role in the development and maintenance of male secondary sexual characteristics. The DHTR, upon binding with DHT, translocates to the cell nucleus. There, it functions as a transcription factor, regulating the expression of target genes involved in various physiological processes. These processes include male reproductive organ development, prostate growth, hair growth patterns, and muscle mass. The receptor is widely expressed in tissues with androgen sensitivity, such as the prostate, skin, muscle, and bone. Variations or dysregulation of the DHTR can be implicated in androgen-related conditions. For instance, it is a key target in the treatment of prostate cancer, where androgen signaling, mediated by the DHTR, often drives tumor growth. Inhibition of DHTR activity is a common therapeutic strategy in this context.