diaped

Diaped refers to the process by which leukocytes, or white blood cells, move from the bloodstream into surrounding tissues. This movement is crucial for the immune system's ability to respond to infection and inflammation. Diapedesis is a multi-step process. First, leukocytes circulating in blood vessels slow down and adhere to the inner lining of the vessel, a process called margination and adhesion. This is often triggered by chemical signals released at the site of injury or infection. Next, the leukocyte flattens and squeezes between the endothelial cells that form the blood vessel wall. This passage can occur through either a paracellular route, moving between cells, or a transcellular route, passing directly through an endothelial cell. Once in the surrounding tissue, the leukocyte can migrate towards the source of the inflammatory or infectious stimulus through a process called chemotaxis. Diapedesis is a fundamental mechanism for delivering immune cells to where they are needed most to combat pathogens and initiate repair processes.