cryoprotektortoxicitás
Cryoprotectant toxicity refers to the harmful effects that cryoprotective agents (CPAs) can have on cells and tissues when used for cryopreservation. CPAs are substances like glycerol, dimethyl sulfoxide (DMSO), and ethylene glycol that are added to biological samples to prevent ice crystal formation during freezing. While essential for protecting cells from damage caused by ice, CPAs themselves can be toxic at certain concentrations or during prolonged exposure.
The toxicity of CPAs can manifest in several ways. They can disrupt cell membranes, leading to leakage
Strategies to mitigate cryoprotectant toxicity include optimizing CPA concentrations and exposure times, using mixtures of CPAs