crac
CRAC is an acronym used in several domains, but it is most commonly associated with calcium release-activated calcium channels in biology. CRAC channels mediate calcium entry into cells when calcium stores in the endoplasmic reticulum are depleted. The channel is formed by Orai proteins and is regulated by STIM proteins, which sense store depletion and activate the channel at the plasma membrane.
In cellular signaling, CRAC channels drive store-operated calcium entry (SOCE), a fundamental pathway that supports diverse
Clinical and research relevance is significant because dysregulation of CRAC channel activity is linked to diseases
Other uses: CRAC is an acronym that can have meanings beyond biology, depending on context. Because acronyms