ceruloplasmiini

Ceruloplasmiini is a globulin protein that is synthesized in the liver. It is the main copper-binding protein in the blood and plays a crucial role in copper transport and metabolism. Approximately 90% of the copper in plasma is bound to ceruloplasmin. Besides its function in copper transport, ceruloplasmin also exhibits ferroxidase activity, meaning it can oxidize ferrous iron (Fe2+) to ferric iron (Fe3+). This oxidation is important for the mobilization of iron from storage sites and its transport to tissues. Ceruloplasmin is an acute-phase reactant, meaning its levels can increase in response to inflammation or infection. Normal levels are typically between 20 and 60 mg/dL. Low levels of ceruloplasmin can be indicative of Wilson's disease, a genetic disorder characterized by excessive copper accumulation in the body, or Menkes disease, another genetic disorder affecting copper metabolism. Conversely, elevated levels can be seen in conditions such as inflammation, certain cancers, and iron deficiency anemia. Measurement of ceruloplasmin is often performed as part of a diagnostic workup for copper-related disorders and inflammatory conditions.