bradykininrelated
Bradykinin-related peptides are a group of biologically active compounds derived from the kinin system, a part of the body’s broader inflammatory and pain response mechanisms. Bradykinin itself is a potent nonapeptide (composed of nine amino acids) that plays a key role in mediating inflammation, vasodilation, and pain perception. It is generated from its precursor, high-molecular-weight kininogen (HMWK), through the action of enzymes such as kallikrein. Bradykinin binds to two primary receptor subtypes, B1 and B2, which are widely expressed in various tissues, including blood vessels, nerves, and immune cells.
The B2 receptor is constitutively expressed and is primarily responsible for the acute effects of bradykinin,
Bradykinin-related peptides include des-Arg9-bradykinin, a metabolite formed by the removal of the C-terminal arginine residue, which
Research into bradykinin-related peptides has led to the development of therapeutic strategies, including the use of