basichelixloophelix
The basic helix-loop-helix (bHLH) is a protein domain found in many transcription factors. It is characterized by two distinct alpha-helical regions separated by a loop of variable length. The basic region is rich in basic amino acids, such as arginine and lysine, and is responsible for DNA binding. The helix-loop-helix region mediates protein dimerization, allowing bHLH proteins to bind to DNA as dimers. These dimers can recognize specific DNA sequences called E-box motifs (CANNTG).
bHLH proteins play crucial roles in regulating gene expression across a wide range of biological processes,
The dimerization of bHLH proteins can occur between two identical proteins (homodimers) or between two different