amphoteriseen

Amphotericin B is a polyene antibiotic used to treat serious fungal infections. It works by binding to ergosterol, a component of fungal cell membranes, which disrupts the membrane's integrity and leads to cell death. Amphotericin B is typically administered intravenously and is often used in combination with other antifungal drugs to improve efficacy and reduce toxicity. It is effective against a wide range of fungal pathogens, including Candida species, Aspergillus, and Cryptococcus.

The most common side effects of amphotericin B include fever, chills, nausea, vomiting, and kidney problems. More severe side effects can occur, such as allergic reactions, liver damage, and electrolyte imbalances. Due to its potential for toxicity, amphotericin B is usually reserved for severe or life-threatening infections that do not respond to other treatments.

Amphotericin B was first isolated from Streptomyces nodosus in 1956. It has since been modified to create more stable and less toxic derivatives, such as amphotericin B deoxycholate and liposomal amphotericin B. These formulations have improved safety profiles and are often preferred for treating fungal infections.