aminolizie

Aminoglycosides are a class of antibiotics that are effective against a wide range of Gram-negative bacteria. They work by binding to the 30S subunit of the bacterial ribosome, inhibiting protein synthesis and ultimately leading to bacterial cell death. The most commonly used aminoglycosides include gentamicin, tobramycin, amikacin, and streptomycin. These antibiotics are often used to treat severe infections such as pneumonia, meningitis, and bacterial sepsis. However, their use is limited by the risk of nephrotoxicity and ototoxicity, which can cause damage to the kidneys and ears, respectively. Additionally, the development of bacterial resistance to aminoglycosides is a significant concern, as it can limit their effectiveness in treating infections. Despite these limitations, aminoglycosides remain an important component of the antibiotic armamentarium, particularly in the treatment of severe and life-threatening infections.