aliskireen

Aliskiren is a medication used to treat high blood pressure, also known as hypertension. It belongs to a class of drugs called direct renin inhibitors. Renin is an enzyme produced by the kidneys that plays a crucial role in the renin-angiotensin-aldosterone system (RAAS), a hormonal cascade that regulates blood pressure and fluid balance. By directly inhibiting renin, aliskiren reduces the production of angiotensin I and angiotensin II, hormones that cause blood vessels to constrict and increase blood pressure. This leads to a decrease in blood pressure.

Aliskiren is available by prescription and is typically taken once daily. It can be used alone or in combination with other blood pressure medications, such as diuretics or angiotensin receptor blockers (ARBs). It is important to take aliskiren exactly as prescribed by a healthcare professional and to not stop taking it without consulting them, even if blood pressure readings improve.

Common side effects of aliskiren may include diarrhea, nausea, cough, and rash. More serious side effects, though less common, can include angioedema, a swelling of the face, lips, tongue, or throat, which requires immediate medical attention. Aliskiren should not be used during pregnancy due to the risk of harm to the fetus. Individuals with a history of angioedema or certain kidney or liver problems should discuss these concerns with their doctor before starting aliskiren. Regular monitoring of blood pressure and kidney function is often recommended while taking this medication.