aggresomal
Aggresomes are discrete, highly organized cytoplasmic inclusions that form in response to the accumulation of misfolded or damaged proteins. These structures are typically found near the nucleus and are characterized by a dense core surrounded by a proteinaceous shell. The formation of aggresomes is a cellular defense mechanism aimed at sequestering potentially toxic protein aggregates, thereby preventing their spread and damage to cellular functions.
The process of aggresome formation is often linked to the ubiquitin-proteasome system (UPS) and autophagy, two
Upon formation, aggresomes can act as a temporary holding site for these aggregates. In some cases, the
Aggresomes have been implicated in the pathogenesis of several neurodegenerative diseases, including Huntington's disease, Alzheimer's disease,