aFGF

aFGF, also known as fibroblast growth factor 9 (FGF9), is a member of the fibroblast growth factor family. These proteins play crucial roles in various biological processes including cell growth, differentiation, migration, and survival. aFGF is primarily involved in the development and maintenance of several organ systems. It is particularly important in the development of the lungs, where it influences branching morphogenesis, and in the nervous system, contributing to neuronal survival and development. Additionally, aFGF has been implicated in the development of the skeletal system and in regulating the growth of certain tissues. The signaling pathway activated by aFGF typically involves binding to specific fibroblast growth factor receptors (FGFRs) on the cell surface, which then initiates intracellular signaling cascades. Dysregulation of aFGF or its signaling pathway has been associated with various developmental disorders and diseases, highlighting its significance in maintaining normal physiological functions. Research continues to explore its therapeutic potential in regenerative medicine and the treatment of certain conditions.