ZNRF1

ZNRF1, also known as zinc and ring finger domain containing protein 1, is a protein encoded by the ZNRF1 gene in humans. It belongs to the RING-type E3 ubiquitin ligase family, a group of enzymes crucial for protein degradation through the ubiquitination pathway. ZNRF1 plays a role in regulating various cellular processes, including cell cycle progression and DNA repair. It is believed to exert its functions by targeting specific proteins for degradation by the proteasome. Research has indicated that ZNRF1 can interact with other proteins involved in DNA damage response pathways, suggesting its involvement in maintaining genomic stability. Dysregulation of ZNRF1 has been implicated in certain diseases, including some types of cancer, although the exact mechanisms are still under investigation. Further studies are ongoing to fully elucidate the precise functions and biological significance of ZNRF1 in both normal cellular physiology and disease pathogenesis.