Yra1

Yra1 is a protein-coding gene in yeast, specifically Saccharomyces cerevisiae, that plays a crucial role in the regulation of RNA polymerase I (Pol I) and RNA polymerase III (Pol III). It is a component of the RNA polymerase I and III transcription machinery, and it is essential for the initiation and regulation of transcription by these polymerases. The Yra1 protein is involved in the assembly of the preinitiation complex and the recruitment of other transcription factors to the promoter regions of rRNA and tRNA genes.

The Yra1 gene is located on chromosome VII of Saccharomyces cerevisiae. It encodes a protein of 665 amino acids with a molecular weight of approximately 75 kDa. The Yra1 protein contains several conserved domains, including a RNA recognition motif (RRM) and a coiled-coil domain, which are important for its function in transcription regulation.

Yra1 is also known to interact with other proteins involved in transcription, such as Rrn3, Rrn7, and Tfc3, which are components of the Pol I and Pol III transcription machinery. These interactions are essential for the proper assembly and function of the transcription preinitiation complex. Mutations in the Yra1 gene can lead to defects in rRNA and tRNA synthesis, which can have severe consequences for cell growth and viability.

In addition to its role in transcription regulation, Yra1 has been implicated in other cellular processes, such as DNA repair and cell cycle progression. However, the exact mechanisms by which Yra1 contributes to these processes are not yet fully understood. Further research is needed to elucidate the full range of functions and regulatory mechanisms of the Yra1 protein.