Yohimbiinis

Yohimbiinis is a chemical compound found in the bark of the Yohimbe tree (Pausinystalia johimbe). It is also known by its IUPAC name, methyl 17-hydroxyallohimban-16-carboxylate. Yohimbiinis is an alkaloid and is the primary active component of Yohimbe bark, which has been traditionally used in West Africa for various medicinal purposes.

The compound is structurally related to other indole alkaloids. It acts as an alpha-2 adrenergic receptor antagonist, meaning it blocks the action of adrenaline and noradrenaline at these specific receptors. This pharmacological action is believed to be responsible for many of the effects associated with yohimbe and yohimbiinis.

Yohimbiinis has been investigated for several potential applications, most notably its use as an aphrodisiac and for treating erectile dysfunction. Its mechanism in this regard is thought to involve increased blood flow to the genital area. However, scientific evidence supporting these uses is mixed, and its effectiveness can vary.

In addition to its potential aphrodisiac properties, yohimbiinis has also been studied for its effects on weight loss, particularly the reduction of stubborn fat. The proposed mechanism involves increasing lipolysis, the breakdown of fat. Nevertheless, robust clinical evidence for significant weight loss benefits is limited.

It is important to note that yohimbiinis and products containing it can have significant side effects. These can include increased heart rate, elevated blood pressure, anxiety, dizziness, and gastrointestinal issues. Due to these potential risks, caution is advised, and medical consultation is recommended before use. The sale and regulation of yohimbe-containing products vary by country.