VWFplatelet
VWFplatelet refers to the interaction between von Willebrand factor (VWF) and platelets, a crucial process in hemostasis and thrombosis. Von Willebrand factor is a multimeric glycoprotein that plays a dual role in blood clotting. It acts as a bridge, facilitating platelet adhesion to damaged blood vessel walls, and it also serves as a carrier protein for coagulation factor VIII. Platelets are small, anucleated cell fragments derived from megakaryocytes.
Upon vascular injury, exposed subendothelial collagen and other matrix components activate VWF. Activated VWF then binds
The VWF-platelet interaction is tightly regulated. Defects in VWF or its platelet receptors can lead to bleeding