VPS18

VPS18, also known as Vascular Permeability Factor 18, is a protein that plays a crucial role in the regulation of vascular permeability. It is a member of the C1q and TNF-related (CTR) protein family, which includes several proteins involved in inflammation and immune responses. VPS18 is primarily expressed in endothelial cells, the cells that line the interior surface of blood vessels.

The primary function of VPS18 is to regulate the permeability of blood vessels. It achieves this by interacting with other proteins involved in the endothelial barrier, such as VE-cadherin and occludin. VPS18 can either enhance or inhibit vascular permeability depending on the cellular context and the presence of other regulatory proteins.

VPS18 is also involved in the inflammatory response. It can be upregulated in response to various inflammatory stimuli, such as cytokines and bacterial lipopolysaccharides. This upregulation can contribute to the increased vascular permeability observed in inflammatory conditions.

The exact mechanisms by which VPS18 regulates vascular permeability are not fully understood. However, it is believed to involve the modulation of endothelial cell junctions and the regulation of intracellular signaling pathways.

VPS18 has been studied in various contexts, including its potential role in diseases such as atherosclerosis, cancer, and inflammatory bowel disease. However, more research is needed to fully understand its functions and potential therapeutic applications.