Ubiquitinylierung
Ubiquitinylation is a post-translational modification process in which ubiquitin, a small protein, is covalently attached to a target protein. This modification plays a crucial role in various cellular processes, including protein degradation, signal transduction, and gene regulation. Ubiquitinylation is mediated by a series of enzymes known as E1 (ubiquitin-activating), E2 (ubiquitin-conjugating), and E3 (ubiquitin ligase) enzymes. The process involves the formation of an isopeptide bond between the carboxyl group of a lysine residue on the target protein and the amino group of ubiquitin.
There are several types of ubiquitin chains that can be formed during ubiquitinylation, including linear, branched,
Ubiquitinylation is a highly regulated process, and its dysregulation has been linked to various diseases, including