U26D2

U26D2, also known as Unc-51-like kinase 2 (ULK2), is a serine/threonine kinase that plays a crucial role in autophagy, a cellular process responsible for degrading and recycling damaged organelles and proteins. It is a member of the ULK kinase family, which also includes ULK1, ULK3, and ULK4. ULK2 is primarily activated by AMP-activated protein kinase (AMPK) and mTOR, key regulators of cellular energy status.

The involvement of U26D2 in autophagy initiation makes it a significant factor in cellular homeostasis and stress response. Studies have indicated that U26D2 is involved in various cellular processes beyond autophagy, including cell migration, differentiation, and apoptosis. Its dysregulation has been linked to several diseases, including cancer, neurodegenerative disorders, and metabolic diseases. Research into U26D2 continues to explore its multifaceted roles in cellular function and its potential as a therapeutic target.