TssF

TssF is a protein component of the Type VI secretion system (T6SS) found in various Gram-negative bacteria. The T6SS is a complex molecular machine that bacteria use to translocate effector proteins directly into neighboring cells, including eukaryotic host cells and other bacterial species. TssF is an integral part of the T6SS apparatus, specifically contributing to the structure and function of the baseplate, which is located in the bacterial inner membrane.

The baseplate is a crucial platform that anchors the T6SS and facilitates the assembly of the contractile tail sheath, which propels the inner tube and puncturing tip into the target cell. TssF is known to interact with other baseplate proteins, such as TssE, TssK, and TssL, to form a stable and functional structure. It plays a role in the proper assembly and organization of these components. While its precise function within the baseplate is still under investigation, TssF is considered essential for T6SS assembly and activity in many bacterial species. Its presence and role are vital for the virulence and interbacterial competition capabilities conferred by the T6SS.