Tm5k

Tm5k is a protein found in many organisms, including humans. Its full name is T-complex polypeptide 1 (TCP1) ring complex subunit theta-like 5. This protein is a component of the T-complex polypeptide 1 ring complex, also known as the CCT complex or TRiC. The TRiC complex is a molecular chaperone that plays a crucial role in protein folding. Molecular chaperones assist other proteins in achieving their correct three-dimensional structure, which is essential for their function.

The TRiC complex is an assembly of eight different subunits, and Tm5k is one of them. It is thought to be involved in the folding of specific types of proteins, particularly those that are prone to aggregation or misfolding. The precise mechanisms by which Tm5k contributes to TRiC's function are still an area of active research. Studies have investigated its interactions with other subunits and its role in binding to unfolded or partially folded polypeptide chains.

Mutations or alterations in the Tm5k gene or its expression levels have been linked to various cellular processes and potential disease states. For instance, disruptions in protein folding pathways are implicated in neurodegenerative diseases and cancer. Research into Tm5k and the TRiC complex contributes to our broader understanding of cellular protein homeostasis and the consequences of its disruption.