Tip60p400

TIP60p400 is a specialized antibody used in scientific research to detect the TIP60 protein, also known as KAT5. TIP60 is a histone acetyltransferase involved in multiple cellular processes, including DNA repair, gene transcription regulation, and apoptosis. It plays a critical role in maintaining genomic stability and modulating chromatin structure.

The "p400" designation indicates that this antibody is specific for an isoform of TIP60 referred to as p400. TIP60 p400 is associated with a large multi-protein complex known as the p400 complex, which includes the TIP60 enzyme and other components that facilitate chromatin remodeling and DNA repair mechanisms.

TIP60p400 antibodies are commonly employed in experiments such as Western blotting, immunoprecipitation, and immunofluorescence to study TIP60’s expression, localization, and interactions within cells. Their specificity allows researchers to analyze the functional roles of TIP60p400 in various biological contexts, including cancer research, neurodegenerative diseases, and cellular response to DNA damage.

Manufacturers of TIP60p400 antibodies typically produce monoclonal or polyclonal variants, offering different applications and sensitivities. Proper validation and control experiments are recommended to ensure target specificity in experimental procedures. Overall, TIP60p400 antibodies are valuable tools for elucidating the molecular mechanisms underlying chromatin modification and DNA repair pathways mediated by TIP60.

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