Testisetin

Testisetin is a peptide hormone produced by the interstitial cells of Leydig in the testes of males. It plays a crucial role in the regulation of spermatogenesis, the process by which sperm cells are produced. Testisetin is also known as inhibin B, a member of the inhibin family of hormones. It is a dimeric protein consisting of two identical alpha-subunits, each of which is composed of 138 amino acids.

The primary function of testisetin is to inhibit the release of follicle-stimulating hormone (FSH) from the pituitary gland. This negative feedback mechanism helps to regulate the production of sperm and maintain the balance between sperm production and release. Testisetin levels are highest during the early stages of spermatogenesis and decrease as sperm production progresses.

Testisetin has been studied for its potential therapeutic applications. It has been shown to have anti-cancer properties, particularly in the treatment of prostate cancer. Additionally, testisetin has been investigated for its potential use in the treatment of infertility and other reproductive disorders. However, further research is needed to fully understand its mechanisms of action and to determine its safety and efficacy in clinical settings.