TRM61

Trm61 is a protein-encoding gene found in *Saccharomyces cerevisiae* (baker's yeast), a model organism widely used in biological research. The gene was first identified through its role in the transport of amino acids across the cell membrane. Specifically, Trm61 is associated with the tRNA methyltransferase complex, which is involved in the post-transcriptional modification of transfer RNA (tRNA). These modifications are essential for proper tRNA function, including accurate codon-anticodon pairing during protein synthesis.

The Trm61 protein is part of a larger complex that catalyzes the methylation of guanine residues in tRNA, a process critical for maintaining tRNA stability and ensuring efficient translation. Mutations or disruptions in the *TRM61* gene can lead to defects in tRNA modification, resulting in slowed growth, reduced protein synthesis efficiency, and potential translational errors in yeast cells. Research on Trm61 has contributed to broader understanding of tRNA biogenesis and the molecular mechanisms underlying protein translation.

Beyond yeast, homologs of Trm61 have been identified in other eukaryotic organisms, suggesting a conserved role in tRNA modification across species. Studies on Trm61 have also provided insights into how cells regulate protein synthesis under varying environmental conditions, such as nutrient availability or stress responses. The gene remains an important subject in molecular biology, particularly in investigations of tRNA metabolism, translational control, and the functional consequences of RNA modifications.