TPN13

TPN13, also known as tropomyosin 13, is a protein that plays a crucial role in muscle contraction. It is a member of the tropomyosin family, which includes several isoforms found in various tissues. TPN13 is primarily expressed in skeletal muscle, where it forms a complex with troponin and actin, facilitating the interaction between actin and myosin during muscle contraction.

The gene encoding TPN13 is located on chromosome 19q13.2 in humans. Mutations in the TPN13 gene have been associated with several muscle disorders, including myopathy and dystrophy. These mutations can lead to impaired muscle function, weakness, and atrophy.

TPN13 is a highly conserved protein, with homologs found in various species, including mammals, birds, reptiles, and fish. Its structure consists of an N-terminal domain, a central coiled-coil domain, and a C-terminal domain. The central coiled-coil domain is responsible for the interaction with troponin and actin.

In summary, TPN13 is a vital protein in skeletal muscle contraction, and mutations in its gene can result in muscle disorders. Its structure and function are well-conserved across different species. Further research is needed to fully understand the molecular mechanisms underlying TPN13's role in muscle function and the impact of its mutations on muscle disorders.