TGB1B

TGB1B, also known as T-cell glycoprotein 1 beta, is a protein encoded by the TGB1B gene in humans. It is a member of the tetraspanin family of proteins, which are characterized by their ability to form tetramers and their role in cell adhesion and signaling. TGB1B is primarily expressed on the surface of T cells, where it plays a crucial role in T cell activation and function. It interacts with other tetraspanins and integrins to regulate T cell adhesion to antigen-presenting cells and to other cells in the immune system. TGB1B is also involved in the regulation of T cell proliferation and differentiation, and its expression is modulated by various cytokines and signaling pathways. Dysregulation of TGB1B has been implicated in the pathogenesis of autoimmune diseases and certain types of cancer. The TGB1B gene is located on chromosome 19q13.4 and consists of 10 exons. Mutations in the TGB1B gene have been associated with an increased risk of developing certain types of cancer, including breast and ovarian cancer. However, the exact mechanisms by which TGB1B contributes to cancer development are not yet fully understood. Overall, TGB1B is a critical regulator of T cell function and immune responses, and its dysregulation can have significant implications for human health.