TETmediated
TETmediated refers to biological processes influenced or regulated by members of the TET (Ten-Eleven Translocation) enzyme family. The TET proteins are a group of dioxygenases that play a crucial role in epigenetic regulation, primarily by oxidizing 5-methylcytosine (5mC), the most common DNA methylation mark, to 5-hydroxymethylcytosine (5hmC) and subsequently to other oxidized derivatives like 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). This iterative oxidation process is a key step in DNA demethylation, a dynamic mechanism that modifies the epigenome.
TETmediated processes are involved in a wide range of cellular functions, including embryonic development, cell differentiation,