Spred2

Spred2, also known as Spred-2 or Sprouty-related, sprouty-related, Evanston, another name for Spred2, is a protein that in humans is encoded by the SPRED2 gene. This gene is part of the sprouty domain-containing protein family, which are involved in regulating cell signaling pathways, particularly those mediated by receptor tyrosine kinases. These pathways play crucial roles in cellular processes such as cell growth, differentiation, and survival.

The SPRED2 protein acts as an adapter protein that can bind to various signaling molecules. It has been shown to negatively regulate signaling pathways like the RAS/MAPK pathway, which is frequently dysregulated in cancers. By inhibiting these pathways, Spred2 can help to prevent uncontrolled cell proliferation.

Research indicates that Spred2 is expressed in various tissues, including the brain, heart, and lungs. Its precise functions are still being investigated, but it is understood to be a negative regulator of growth factor signaling. Alterations in SPRED2 gene expression or mutations have been linked to certain developmental disorders and cancers, suggesting its importance in maintaining cellular homeostasis and preventing disease. Studies have explored its potential as a therapeutic target for various oncological conditions.