Spin10

Spin10 is a protein that plays a role in cell division and chromosome segregation. It is a component of the inner kinetochore, a complex structure that assembles at the centromere of chromosomes and attaches them to spindle microtubules. Spin10 is thought to contribute to the structural integrity of the kinetochore and its interaction with the mitotic spindle. Mutations or misregulation of Spin10 have been linked to chromosomal instability, a hallmark of many cancers. The precise mechanisms by which Spin10 functions within the kinetochore are still under investigation, but research suggests it interacts with other kinetochore proteins to ensure proper chromosome movement during mitosis. Understanding Spin10's role is crucial for comprehending the fundamental processes of cell division and for developing strategies to target cancer cells with chromosomal abnormalities.