Sfi1pCdc31p

Sfi1pCdc31p refers to a complex or interaction between two proteins, Sfi1p and Cdc31p, in the yeast *Saccharomyces cerevisiae*. Sfi1p is a component of the spindle pole body (SPB), which is the yeast equivalent of the centrosome. The SPB is a crucial microtubule-organizing center involved in nuclear division. Cdc31p, also known as the yeast calmodulin, is a calcium-binding protein that plays a role in various cellular processes, including cell cycle progression and SPB duplication. The interaction between Sfi1p and Cdc31p is important for the proper duplication and segregation of the SPB. Studies have shown that Cdc31p localizes to the SPB and is required for its duplication. Sfi1p, in turn, is essential for anchoring components of the SPB, including Cdc31p, to the spindle pole body. This partnership ensures that the duplicated SPBs are correctly organized and segregated to daughter cells during mitosis. Defects in the Sfi1pCdc31p interaction can lead to problems with SPB duplication, spindle formation, and ultimately, cell cycle arrest or lethality. Research into this complex continues to shed light on the intricate mechanisms governing centrosome/SPB duplication and function.