Secretomers

Secretomers are a class of secreted proteins that possess a specific type of three-dimensional structure. This structure is characterized by a beta-roll motif, which is an arrangement of beta-strands that form a helical conformation. This unique structural feature allows secretomers to interact with various biological molecules, including other proteins and lipids.

The primary function of secretomers is to mediate cell-cell communication and to participate in the assembly of the extracellular matrix. They play crucial roles in a variety of biological processes such as cell adhesion, cell migration, immune response, and tissue development. Due to their involvement in these fundamental processes, secretomers are implicated in a range of physiological and pathological conditions.

Dysregulation in the production or function of secretomers has been linked to diseases like cancer, inflammatory disorders, and neurodegenerative conditions. Research into secretomers is ongoing, with a focus on understanding their precise mechanisms of action and exploring their potential as therapeutic targets. Their ability to interact with other biomolecules makes them attractive candidates for drug development, particularly in areas where modulating cell signaling or extracellular matrix remodeling is desired.