Sec1331p

Sec1331p is a protein found in the yeast Saccharomyces cerevisiae. It is a component of the Sec13-like protein complex, also known as the COPII coatomer. This complex plays a crucial role in the formation of COPII-coated vesicles, which are essential for the transport of proteins and lipids from the endoplasmic reticulum to the Golgi apparatus. Sec1331p specifically contributes to the structural integrity of the COPII coat, facilitating the budding of vesicles from the ER membrane.

The Sec13-like protein family is conserved across eukaryotes, suggesting a fundamental role in intracellular trafficking. Sec1331p, along with its interacting partners like Sec13, Sec31, and Sar1, assembles into a cage-like structure that surrounds and shapes the budding vesicle. This process is vital for maintaining cellular organization and ensuring that newly synthesized proteins reach their correct destinations. Mutations or defects in Sec1331p function can lead to impaired protein transport and cellular dysfunction. Research into Sec1331p and the COPII machinery continues to shed light on the intricate mechanisms of protein trafficking within eukaryotic cells.