STKLD1

STKLD1, also known as Stkld1 or Stkld1-like, is a gene located on chromosome 17q21.3. It encodes a protein involved in the regulation of cell proliferation and differentiation. The STKLD1 gene is a member of the STK family, which includes several serine/threonine kinases. The encoded protein, STKLD1, is a non-receptor tyrosine kinase that plays a crucial role in various cellular processes, including cell cycle regulation, apoptosis, and cell migration.

Mutations in the STKLD1 gene have been associated with several diseases, including cancer and developmental disorders. In cancer, STKLD1 is often overexpressed, leading to uncontrolled cell growth and proliferation. In developmental disorders, mutations in STKLD1 can disrupt normal cell differentiation and lead to various developmental abnormalities.

The STKLD1 protein is a homodimer, and its kinase activity is regulated by various mechanisms, including phosphorylation and interaction with other proteins. The STKLD1 protein has been shown to interact with several proteins, including p53, p21, and p27, which are involved in cell cycle regulation and apoptosis.

In summary, STKLD1 is a gene that encodes a protein involved in the regulation of cell proliferation and differentiation. Mutations in the STKLD1 gene have been associated with several diseases, including cancer and developmental disorders. The STKLD1 protein is a homodimer, and its kinase activity is regulated by various mechanisms.