ST8SIA3

ST8SIA3, also known as SIAT3 or ST8 alpha-N-acetyl-neuraminidate alpha-2,3-sialyltransferase 3, is an enzyme encoded by the ST8SIA3 gene. This gene is located on human chromosome 16. ST8SIA3 is a member of the alpha-2,3-sialyltransferase family, which are glycosyltransferases responsible for the synthesis of sialic acids. Sialic acids are a group of negatively charged nine-carbon sugar derivatives that play crucial roles in various biological processes.

The enzyme ST8SIA3 catalyzes the transfer of sialic acid from a donor molecule, typically cytidine monophosphate-N-acetylneuraminic acid (CMP-Neu5Ac), to acceptor molecules. Specifically, it is involved in the formation of alpha-2,3-sialyl linkages. These linkages are important for the structure and function of glycoproteins and glycolipids. The resulting sialylated structures can influence cell-cell recognition, immune responses, and cell signaling pathways.

Expression of ST8SIA3 has been observed in various tissues, including the brain, liver, and kidneys. Its activity is thought to be important for normal development and physiological function. Dysregulation or mutations in the ST8SIA3 gene have been associated with certain neurological disorders, suggesting a role in neuronal development and function. Research into the precise functions and disease associations of ST8SIA3 is ongoing.