SGLT3

Sodium-glucose cotransporter 3, also known as SGLT3, is a protein encoded by the SLC5A3 gene in humans. Unlike other members of the SGLT family, SGLT3 is not primarily involved in glucose reabsorption in the kidneys or absorption in the intestines. Instead, it is thought to function as a glucose sensor, particularly in the nervous system. Its expression has been detected in various tissues, including the brain, pancreas, and gastrointestinal tract. Research suggests that SGLT3 plays a role in detecting luminal glucose concentrations and may trigger downstream signaling pathways. These pathways are implicated in regulating various physiological processes, including appetite, insulin secretion, and intestinal motility. The exact molecular mechanisms by which SGLT3 senses glucose and initiates these responses are still under investigation. However, studies indicate that its activity is independent of sodium cotransport. Alterations in SGLT3 function have been hypothesized to contribute to metabolic disorders, although its precise role in human disease remains an active area of research.