SDF1alphaCXCR4
SDF1alphaCXCR4 refers to the interaction between Stromal Cell-Derived Factor 1 alpha (SDF1alpha), also known as CXCL12, and its primary receptor, Chemokine Receptor Type 4 (CXCR4). This signaling pathway plays a crucial role in various biological processes, including embryonic development, immune cell trafficking, and stem cell homing. SDF1alpha is a potent chemoattractant, guiding cells expressing CXCR4 to locations where SDF1alpha is present.
The SDF1alphaCXCR4 axis is vital for the development and function of the immune system, particularly in the
For instance, in cancer, this pathway is frequently dysregulated and contributes to tumor growth, metastasis, and