Reservestamcelbestand

Reservestamcelbestand refers to a reserve stock of stem cells kept by a biobank, transplant program, or research facility to ensure available material for future therapeutic use, testing, or development.

The most common form is hematopoietic stem cells (HSCs) used for transplantation in treating leukemias, lymphomas, and severe aplastic anemia. Sources include cord blood, bone marrow, and mobilized peripheral blood. A reserve stock may contain samples from multiple donors to increase matching possibilities.

Storage involves cryopreservation in liquid nitrogen at very low temperatures, with quality control, testing for pathogens, HLA typing, and documentation. Autologous reserves are sometimes created for patients undergoing planned high-dose therapy, while allogeneic reserves are stored for potential unrelated donors or family donors.

Uses include allogeneic transplants, autologous rescue, and research; reserves may also support advances in regenerative medicine and gene therapy.

Ethical and legal considerations include informed consent, privacy, ownership, access rules, and regulatory compliance for storage, transport, and use across borders.

Limitations involve potential loss of cell viability over time, costs, logistical challenges, and the risk of immune complications such as graft-versus-host disease; stored material is not guaranteed to be usable in every case.