RRE

RRE is an acronym used for several terms across different disciplines. In molecular biology, RRE most commonly refers to the Rev Response Element, a cis-acting RNA sequence within the HIV-1 genome that binds the regulatory protein Rev to regulate nuclear export of viral mRNAs.

The Rev Response Element is located within the env gene region of the HIV-1 RNA and is essential for the export of unspliced and incompletely spliced transcripts from the nucleus to the cytoplasm. By binding Rev, the RRE recruits cellular export machinery, notably the CRM1 export receptor, enabling the production of structural proteins and replication-competent genomes necessary for viral assembly. The RRE forms a defined RNA secondary structure composed of multiple stem-loop elements, and its activity can differ among HIV-1 subtypes, influencing replication efficiency.

In research, the RRE is studied to understand RNA-protein interactions, RNA export, and potential antiviral strategies aimed at inhibiting Rev-RRE function. Mutations in the RRE can alter Rev binding and export efficiency, affecting viral gene expression.

Outside biology, RRE is an acronym used in other domains to denote different terms, and its meaning should be determined from context. If you encounter RRE in a non-biological setting, consult domain-specific glossaries to identify the intended term.