RAASaktivációhoz

RAASaktivációhoz refers to the activation of the Renin-Angiotensin-Aldosterone System. This is a critical hormonal system that regulates blood pressure and fluid balance in the body. The system is initiated when the kidneys release an enzyme called renin. Renin acts on angiotensinogen, a protein produced by the liver, to form angiotensin I. Angiotensin I is then converted to angiotensin II by an enzyme called angiotensin-converting enzyme (ACE), primarily found in the lungs.

Angiotensin II is a potent vasoconstrictor, meaning it narrows blood vessels, which increases blood pressure. It also stimulates the adrenal glands to release aldosterone. Aldosterone acts on the kidneys, promoting the reabsorption of sodium and water, which further increases blood volume and blood pressure. Additionally, angiotensin II can stimulate thirst and the release of antidiuretic hormone (ADH), both of which contribute to fluid retention.

RAASaktivációhoz can occur in response to various stimuli, including low blood pressure, decreased blood volume, or low sodium levels. While essential for maintaining homeostasis, chronic or excessive activation of the RAAS can contribute to the development or exacerbation of cardiovascular diseases such as hypertension, heart failure, and kidney disease. Therefore, many medications used to treat these conditions, such as ACE inhibitors and angiotensin II receptor blockers (ARBs), work by inhibiting components of the RAAS pathway.