R2NPR2

R2NPR2, also known as Retinaldehyde-binding protein 2, is a protein encoded by the R2NPR2 gene in humans. This gene is located on chromosome 19. The R2NPR2 protein is a member of the aldehyde dehydrogenase superfamily and is primarily expressed in the retina.

Its main function is believed to be related to the metabolism of retinoids, a group of compounds derived from vitamin A. Specifically, R2NPR2 is thought to be involved in the oxidation of retinaldehyde to retinoic acid. Retinoic acid is a crucial signaling molecule that plays a vital role in various developmental processes, including cell differentiation, proliferation, and survival. In the retina, retinoids are essential for vision, participating in the phototransduction cascade.

Dysfunction or mutations in R2NPR2 have been implicated in certain retinal disorders, although research is ongoing. Understanding the precise role of R2NPR2 is important for unraveling the complex pathways of retinoid metabolism and its contribution to maintaining retinal health and visual function. Further studies are needed to fully elucidate its physiological and pathological significance.