PselectinsPselectin
Pselectins are a family of cell adhesion molecules that play a crucial role in inflammation, thrombosis, and immune responses. There are three known pselectins: P-selectin (CD62P), E-selectin (CD62E), and L-selectin (CD62L). Pselectins are characterized by their ability to bind to sialylated ligands, which are carbohydrates containing sialic acid.
P-selectin is primarily expressed on the surface of platelets and is rapidly induced by inflammatory cytokines
E-selectin is expressed on the surface of endothelial cells and is induced by inflammatory cytokines such as
L-selectin is expressed on the surface of leukocytes and is involved in the rolling, adhesion, and transmigration
Pselectins are important targets for therapeutic intervention in inflammatory and thrombotic diseases. Inhibitors of pselectins, such