PrilezhaevReaktion

The Prilezhaev reaction is a chemical process used in organic synthesis to convert aldehydes into carboxylic acids. It was first reported by the Russian chemist Alexander Prilezhaev in 1871. The reaction involves the oxidation of aldehydes using potassium permanganate (KMnO4) in an acidic medium. The mechanism of the Prilezhaev reaction is not fully understood, but it is believed to involve the formation of a manganese(V) intermediate, which then oxidizes the aldehyde to the carboxylic acid. The reaction is typically carried out at low temperatures to prevent side reactions. The Prilezhaev reaction is useful for the synthesis of carboxylic acids from aldehydes, which are often more readily available than carboxylic acids. However, it is important to note that the reaction can be slow and may require long reaction times. Additionally, the use of potassium permanganate can be hazardous due to its oxidizing properties. The Prilezhaev reaction has been used in the synthesis of various carboxylic acids, including those found in natural products and pharmaceuticals.