Poistomutaatio

Poistomutaatio is a Finnish concept that refers to a type of mutagenesis where the mutation that causes cancer or other harmful effects occurs after DNA duplication, during the process of repair of DNA damage. In other words, it is a type of DNA mutation that occurs during the cell cycle, typically during the S phase.

During poistomutaatio, the error repair of DNA damage leads to an alteration in the DNA sequence, resulting in a mutation. This can occur through various mechanisms, including nucleotide excision repair, base excision repair, or mismatch repair. Poistomutaatio can also involve errors in the replication process itself, such as fork stalling, where the replication fork becomes stuck, leading to errors during DNA synthesis.

Poistomutaatio is considered a type of post-replication repair, as it occurs after DNA replication has taken place. It is also closely related to the concept of post-replication mutagenesis, which refers to any type of mutation that occurs after DNA replication. Poistomutaatio can be caused by exposure to various types of environmental mutagens, including ionizing radiation, UV radiation, and certain chemicals.

Research on poistomutaatio has been conducted to understand its role in the development of cancer and other diseases. Studies have shown that poistomutaatio can contribute to the accumulation of genetic mutations in cells, leading to the initiation and progression of tumors. Further research is needed to fully understand the mechanisms of poistomutaatio and its implications for human health.