Piperidine2carboxylic

Piperidine-2-carboxylic acid, also known as 2-picolinic acid, is a heterocyclic organic compound with the chemical formula C6H9NO2. It is a derivative of piperidine, a six-membered ring containing one nitrogen atom, with a carboxylic acid group attached at the 2-position. This compound is a white crystalline solid that is soluble in water and many organic solvents.

Piperidine-2-carboxylic acid is a versatile intermediate in organic synthesis. It can be used in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. One of its notable applications is in the synthesis of nicotinic acid, a vitamin B3 precursor. It is also used in the preparation of certain dyes and pigments.

The compound can be synthesized through various methods, including the reaction of piperidine with carbon monoxide and oxygen in the presence of a catalyst, or by the oxidation of 2-piperidinecarboxamide. It can also be obtained through the hydrolysis of 2-piperidinecarboxylic acid esters.

Piperidine-2-carboxylic acid is a weak acid, with a pKa value of approximately 4.5. It is stable under normal conditions but can decompose upon heating or under acidic conditions. It is also known to be a potential carcinogen, and its use and handling should be done with appropriate safety measures.