Piletimasin

Piletimasin is a synthetic analog of the natural product pilocarpine, which is derived from the leaves of the pilocarpus jaborandi plant. It is a muscarinic acetylcholine receptor agonist, primarily used in the treatment of dry eye syndrome. Piletimasin works by stimulating the parasympathetic nervous system, which leads to increased tear production and improved lubrication of the eyes.

The drug was first synthesized in the 1980s and has since been studied for its potential therapeutic benefits. It is available in various forms, including eye drops and oral tablets. Piletimasin is generally well-tolerated, with common side effects including blurred vision, eye irritation, and gastrointestinal discomfort. Serious side effects are rare but can include severe allergic reactions and changes in heart rate.

Piletimasin is not approved for use in all countries, and its availability may vary depending on regulatory guidelines and local healthcare practices. It is important for patients to consult with their healthcare provider before starting any new medication, including piletimasin, to ensure it is appropriate for their specific condition and medical history.